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Decitabine for acute myelogenous leukemia – pro

Dacogen (decitabine) is a new drug, a DNA methyltransferase inhibitors (DMTI) that approved by the FDA for use in all French- American British (FAB) categories for MDS. The response rates for Dacogen were 30% (9% CR, 8% PR, 13% HI). Median TTP was prolonged from 7.8 months to 12.1 months compared to supportive care (p=0.1). Higher response rates have been reported in a single institution trial using lower doses of Dacogen. This drug is now FDA approved

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Delay in diagnosis of head and neck cancer – pro

Diagnosis and treatmetn of head and neck cancer is complex and requires co-ordination or providers and resources. Delays in diagnosis is not uncommon. In a Canadian study, median patient, professional and total delays were 4.5 weeks, 11.8 weeks and 22.5 weeks, respectively. Significantly longer delays were found among women(p < 0.01), non-smokers (p < 0.01), patients who were not referred following initial consultation(p < 0.001) and patients

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Hyper CVAD for Burkitts – pro

Standard doxorubicin-based combination chemotherapy, such as CHOP, frequently induces remissions of short duration. The overall CR rate is 915 and induction-therapy mortality was low (6%). In one review the estimated 5-year CR rate was 38% and the estimated 5-year survival rate was 39%. These results were achieved despite broad entrance criteria (no exclusions by age, performance status, organ dysfunction, or infection status at the time of diagnosis).

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Oxycodone – pro

Oxycodone is a full opioid agonist with no antagonist properties whose principal therapeutic action is analgesia. It has an affinity for kappa, mu and delta opiate receptors in the brain and spinal cord. Oxycodone is similar to morphine in its action. Other pharmacological actions of oxycodone are in the CNS (respiratory depression, antitussive, anxiolytic, sedative and miosis), smooth muscle (constipation, reduction in gastric, biliary and pancreatic

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Carfilzomib(Kyprolis), a new drug for myeloma – pro

Carfilzomib(Kyprolis) is a newly approve drug for multiple myeloma. (Onyx Pharmaceuticals) is similar to Velcade. KYPROLIS is indicated for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. It is a proteasome inhibitor that inhibits the breakdown of proteins

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Affirma testing for thyroid cancer 2015 – pro

Veracyte’s Afirma Gene Expression Classifier test demonstrated in a multicenter, prospective validation study, published recently in the New England Journal of Medicine, that when it reclassified thyroid nodule FNA samples that were initially deemed indeterminate by cytopathology as benign which it did more than 50% of the time its accuracy was similar to a benign diagnosis using cytopathology. The majority of FNAs of tyroid nodules show benign

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New drugs for breast cancer: Halaven and Xgeva – pro

Both Halaven and Exjeva are new drugs that were recently approved.   HALAVEN( eribubilin) is indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting. This was based on an open-label, randomized, multicenter trial of

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TDM1- 2012 update -pro

Trastuzumab emtansine (INN), variously called L trastuzumab-DM1 or trastuzumab-MCC-DM1, or  T-DM1 is an antibody-drug conjugate consisting of the antibody trastuzumab (Herceptin) linked to a cytotoxic agent that is a derivative of maytansine (DM1). Is is promising drug and it is in several studies. EMILIA, a phase III trial of 991 people with HER2-positive unresectable locally advanced or metastatic breast cancer, comparing T-DM1 versus capecitabine

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TDM1 – 2012 update

Herceptin and laptinib are two currently available drugs that work in HER+ breast cancer. A way to make anti-HER2 therapy more effective is to combine the antibody that affects the HER2 receptor with a molecule that kills cancer cells. The antibody attaches to the cancer cell HER2 receptor and bring the chemo molecule in proximity to it, which then kills the cell. Trastuzumab emtansine (INN), variousely calledL trastuzumab-DM1 or trastuzumab-MCC-DM1,

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Promacta(eltromopag) for aplastic anemia – pro
doc examining test tube

Aplastic anemia is a difficult to treat disease. Younger patients, those under the age of 50, can proceed to an allogeneic stem cell transplant, but for older patients, the only effective strategy to prevent the complication of underproducing blood cells, is immunosupressive therapy. A recently approved drug for Idiopathic Throbocytopenic Purpura(ITP) can potentially raise platelet counts in aplastic anemia patients and was recently published in

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