Adjuvant Therapy for Early-Stage Marginal Zone Lymphoma

Extranodal marginal zone lymphoma, also called low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), is a lymphoma that, unlike most other lymphomas, arises outside of lymph nodes, in a number of locations, including the stomach, salivary glands, lung and small intestine. There is evidence for marginal zone lymphoma in general that it might be disseminated at presentation. Therefore, it is tempting to prescribe adjuvant chemotherapy or rituximab after the primary site had been treated to a remission. However that is still an experimental approach.

NCCN on p. NGMLT-2 recommends that extranodal marginal zone lymphoma be treated with observation after resection. If margins are close, as they were in this case, NCCN recommends radiation. It does not recommend adjuvant Rituxan.

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