Afinitor for colon cancer

Afinitor is a new exciting drug that is approved for breast and kidney cancer and other conditions. Evidence for using Afinitor for colorectal cancer is weak – one small trial with weak results. There is some evidence from this trial ( Altomare et al) reported in ASCO 2012 that some colorectal cancer patients whose tumors had gotten worse on all standard treatments can benefit from a combination of Afinitor® (everolimus) and Avastin® (bevacizumab). This was a small trial in 50 patients. It showed a tumor control rate of 47%. Median progression-free survival time was 2.28 months, median overall survival time was 7.87 months. 46 percent of patients had disease control that lasted a median of 6.1 months. There were no complete or partial responses. 8  had a minor response lasting median 4.1 months.  15 had stable disease lasting median 6.7 months.

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