Treating with chemotherapy before surgery for breast cancer
Neoadjuvant chemotherapy came into vogue in the seventies and eighties, spurred on by the success of organ preservation strategies in cancers such as laryngeal and rectal cancer. It used to be thought there are two potential benefits of neoadjuvant chemotherapy: downstaging a breast tumor so lesser surgery can be performed - lumpectomy instead of mastectomy, and to potentially treat early occult metastatic disease and to improve survival. The first
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