Germ Cell Tumors

Non-gonadal Germinomas – pro

Germinoma is primarily a disease of young males. There are germinomas that arise in the testicles and those that do not. It is presumed that the non-testicular germinoma have their origin in germ cells left behind during the development of the fetus. The current World Health Organization classification of Germ Cell Tumors (GCT), which is based primarily on histological elements, divides these tumors into the following major forms: Germinoma – Pure

Read more
Extragonadal Germ Cell Tumors: Role of Transplant – pro

High dose chemotherapy with autologous stem cell rescue is an accepted and standard of care approach for relapsed or nonresponding testicular cancer. It is recommended by several guidelines, including NCCN. Extragonadal germinal cell syndromes are rare tumors that predominantly affect young males. Histologically, they mirror their gonadal counterparts with which they share the same chemosensitivity and radiosensitivity. Controversy remains regarding

Read more