BRCA and screening for pancreatic cancer – pro

Certain germline mutations are known to give rise to hereditary pancreatic cancer syndromes including BRCA2,  p16,STK11/LKB1,and PRSS1. There are several other conditions that incrase the risk of pancreatic cacner but this post will focus on BRCA. BRCA2 is a key regulator of gene transcription. Mutation in this gene results in hereditary breast and ovarian cancer syndromes. Over the last 10 years it has been noted that some families with BRCA2 mutations

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Readmission After Pancreaticodudenectomy – pro

The Whipple procedure is a complex and morbid up duration with significant readmission rates. In a recent review of experience at the Johns Hopkins, readmission rates have been decreasing. When early and late complications were compared, patients with early complications were likelier to be readmitted for delayed gastric emptying (12% vs. 4%; P<0.01), intra-abdominal abscess (17% vs. 4%; P<0.0001) and wound infections (6% vs.1%; P< 0.02).

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