Chemotherapy for sinonasal carcinoma – pro

Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses, which has recently been characterized as a distinct pathologic entity. The prognosis for patients with SNUC is poor. There is only case report level information on the usefullness of chemotherapy for this condition and most of these indicate that it is not very effective. Etoposide is supported by a few reports, mostly in combination but without significant reported effectiveness. It can only be considered experimental based on the lack of information and suggestions of it not being effective.

Mamoru Miyaguchia1 Lymph node and distant metastases in patients with sinonasal carcinoma
The Journal of Laryngology & Otology (1995), 109:304-307

Eric R. Schmidt, Ronald L. Berry Diagnosis and Treatment of Sinonasal Undifferentiated Carcinoma: Report of a Case and Review of the Literature
Journal of Oral and Maxillofacial Surgery, Volume 66, Issue 7, July 2008, Pages 1505-1510

Transplantation Proceedings, Volume 40, Issue 10, December 2008, Pages 3821-3822
P. De Simone, L. Coletti, D. Campani, A. Falcone, F. Filipponi Liver Transplantation for Metastatic Sinonasal Undifferentiated Carcinoma: A Case Report

Brian S. Kim et al, Sinonasal Malignancies of Neuroendocrine Origin
Hematology/Oncology Clinics of North America, Volume 22, Issue 6, December 2008, Pages 1297-1316

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