Granular cell tumors – pro

Concept of medical education with book and stethoscope

Granular cell tumor develops on any skin or mucosal surface, but occurs most commonly on the tongue( 40%). Other names for this rare caner are:  Abrikossoff’s tumor, Granular cell myoblastoma, Granular cell nerve sheath tumor, and Granular cell schwannoma. It is now believed to be a neopalstic process. It is called granular because of the accumulation of secondary lysosomes in the cytoplasm. The literature is based on case reports and series and presents the impression that radiation and chemotherapy are not needed for benign lesions and are not effective for malignant lesions.

Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1796, 1804. ISBN 1-4160-2999-0.

Magnetic resonance appearance of granular cell tumor of the breast.

Daniel D Maki, Donna Horne, Lawrence J Damore, Connie Jones Clin Imaging 33(5):395-7 (2009),

Schrader, KA.; Nelson, TN.; De Luca, A.; Huntsman, DG.; McGillivray, BC. (Feb 2009). “Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.”. Clin Genet 75 (2): 1859.

Rejas RA, Campos MS, Cortes AR, Pinto DD, de Sousa SC. The neural histogenetic origin of the oral granular cell tumor: an immunohistochemical evidence. Med Oral Patol Oral Cir Bucal. Jan 1 2011;16(1):e6-10.

25.Narra SL, Tombazzi C, Datta V, et al. Granular cell tumor of the esophagus: report of five cases and review of the literature. Am J Med Sci. May 2008;335(5):338-41

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