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Decitabine for acute myelogenous leukemia – pro

Dacogen (decitabine) is a new drug, a DNA methyltransferase inhibitors (DMTI) that approved by the FDA for use in all French- American British (FAB) categories for MDS. The response rates for Dacogen were 30% (9% CR, 8% PR, 13% HI). Median TTP was prolonged from 7.8 months to 12.1 months compared to supportive care (p=0.1). Higher response rates have been reported in a single institution trial using lower doses of Dacogen. This drug is now FDA approved

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Autologous transplantation for POEMS and Castleman’s Dsease – pro

Several conditions. most commonly Castleman's with about 30% of cases, can be associated with polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndrome, or it can present by itself. High-dose chemotherapy with autologous peripheral blood stem cell transplantation (ASCT) has been reported in case reprots and there are no prospective trials and it can cause considerable peritransplant morbidity. IN 2005 Dr. Dizspenzieri

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CP-675 in melanoma – pro

Overcoming immune tolerance against tumor self-antigens is a goal of intense research in the design of cancer therapies. One approach to enhance immune system activation against tumor antigens is to bl;ock the inhibitory co-stimulatory signals mediated by cytotoxic T lymphocyte antigen 4, (CTLA-4) expressed on activated T cells. The CP-675 is one of several fully human monoclonal antibodies that are directed against human CTLA-4, ipilimumab (Medarex/Bristol-Myers

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Oxycodone – pro

Oxycodone is a full opioid agonist with no antagonist properties whose principal therapeutic action is analgesia. It has an affinity for kappa, mu and delta opiate receptors in the brain and spinal cord. Oxycodone is similar to morphine in its action. Other pharmacological actions of oxycodone are in the CNS (respiratory depression, antitussive, anxiolytic, sedative and miosis), smooth muscle (constipation, reduction in gastric, biliary and pancreatic

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MVAC for bladder cancer – pro

Systemic chemotherapy is the only modality that has been shown in phase 3 trials to improve survival in responding patients with advanced bladder cancer).The M-VAC regimen, first reported in 1985 by investigators from Memorial Sloan-Kettering Cancer Center, revealed that urothelial carcinoma was sensitive to chemotherapy. Patients with measurable lesions were found to have a remarkably high response rate of 72%, and 36% attained complete response.

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Vectibix in combination – pro

Panitumumab (Vectibix, Amgen) was approved by the FDA for the treatment of patients with EGFR-expressing, metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine-, oxaliplatin-, or irinotecan-containing regimens. The NCCN Colon Cancer panel added panitumumab as alternate option to cetuximab after first or second progression on previous therapy. This addition came with a recommendation that patients should not be

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New drugs for breast cancer: Halaven and Xgeva – pro

Both Halaven and Exjeva are new drugs that were recently approved.   HALAVEN( eribubilin) is indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Prior therapy should have included an anthracycline and a taxane in either the adjuvant or metastatic setting. This was based on an open-label, randomized, multicenter trial of

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Interferon for VIPoma – pro

The VIPoma syndrome is rare and difficult to treat and for this reason, ti is not well studied. It is usually caused by a neuroendocrine tumor located in the pancreas or other organs and present primarily with diarrhea. Treatment relies on resection and octreotide but occasionally interferon or steroids can be used as adjuncts (Best Practice, Eppocrates). On the other hand, other reviews do not mention interferon or mention it in combiantion with

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Neutropenia with Ibrance, Kisqalu and Verzenio.

Cyclin-dependent kinase (CDK) 4/6 inhibitors are a class of anticancer medications that can reduce or eliminate endocrine resistance when used in combination with endocrine therapy for the treatment of hormone receptorpositive (HR+) breast cancer. Currently, three CDK4/6 inhibitors are approved for the initial treatment of HR+ advanced breast cancer in combination with an aromatase inhibitor (AI): abemaciclib,[1] palbociclib,[2] or ribociclib[3.

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Neutropenia rate of docetaxel/ cyclophoshamide regimen – pro

The issue in is whether the docetaxel/ cyclophashamide regimen has a febrile neutropenia rate of 20% or more when used in the usual manner in adjuvant treatmetn of breast cancer. The issue is solely whether the docetaxel/ cyclophashamide regimen has a febrile neutrropenai rate of 20% or more when used in the usual manner in adjuvant treatment of breast cancer. The original Journal of Clinical Onology paper(Dec 1 206)reported a febrile nutropenia

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