Cancer Treatment Today » Atyoical CML. CML. Chronic Myelogenous Leukemia http://cancertreatmenttoday.org Knowledge is Power Fri, 24 Apr 2026 13:10:44 +0000 en-US hourly 1 Atypical CML http://cancertreatmenttoday.org/atypical-cml/ http://cancertreatmenttoday.org/atypical-cml/#comments Fri, 03 Jan 2014 20:38:28 +0000 M Levin, MD http://cancertreatmenttoday.org/?p=11779 Atypical chronic myelogenous leukemia (aCML) is a leukemic disorder that exhibits both myelodysplastic and myeloproliferative features at the time of diagnosis. What this means is that it is not truly a CML but a condition that can be confused with CML, but is essentially different. It is not very common. It is thought that these features denote a poor prognosis, but these cases ahve a variety of genetic abnormalities that are different from CML and not much is known about how theya ffect prognosis.  Atypical CML cases are usually BCR-ABL negative. The optimal treatment of aCML is uncertain because of the rare incidence of this chronic leukemic disorder. Treatment with hydroxyurea may lead to short-lived partial remissions of 2- to 4-months’ duration. Atypical CML, appears to respond poorly to treatment with interferon-alpha or other CML treatments.

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