Cytogenetics for myelofibrosis -Pro

Cytogenetics are now routinely recommended for myelofibrosis. Guidelines (Reilly et al) indicate that beyond a routine bone marrow aspiration and biopsy, JAK2 V617F mutation screening should be carried out routinely in patients with primary myelofibrosis (PMF). Quantitative results are not required for clinical management.BCR-ABL1 rearrangement should be excluded in cases with atypical trephine biopsy features, or if the patient lacks a mutation

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Gleevec for P. Vera

Gleevec is a drug initially approved for Chronic Myelogenous Leukemia but also studied for a variety of other conditions. It was studied for P. Vera at Weil-Cornell and the study was published in 2011. It treated 37 patients with polycythemia vera with Gleevec. The overall response rate was 49%. Thirty percent had a complete response, and 19%, a partial response. These are quite good results. On the other hand, a previous study by Nussenzveig et

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Ruxolitinib and Revlimid for myelofibrosis

Myelofibrosis is a Philadelphia chromosome-negative blood condition with a natural history characterized by progressive anemia, spleen enlargement due to production for ed cells there, and potential for evolution to acute myeloid leukemia (AML). For patients who require treatment and are not candidates fostem cell  transplantation, available therapies have not been curative. They include: chemotherapy such as hydroxyurea; erythropoiesis-stimulating

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Imaging Spleen in Myelofibrosis

Myelofibrosis is a bone marrow disorder that disrupts the body’s normal production of blood cells. The result is extensive scarring in the bone marrow, leading to severe anemia, weakness, fatigue, and often, an enlarged spleen and liver. The enlarged spleen can produce symptoms and it can be massive. Occasionally the presenting symptom is pain, feeling full after eating just a little (early satiety), fever and left sided tenderness. It is crucial

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