Chronic neutropenia and Neupogen

Severe chronic neutropenia is a general term that applies to both congenital and acquired cases. Kostman syndrome is a subtype of chronic neutropenia with onset in early childhood with an autosomal recessive pattern of inheritance. It can have an immune basis.  The mainstay of treatment is G-CSF(Neupogen) and many patients do well on it. It is not, however, a curative treatment. Approximately 90% of patients respond to GCSF administration with a

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