Mantle Cell Lymphoma

Azerra for mantle cell lymphoma

Azerra (ofatumumab) is a new antibiody against Chronic lymphocytic leukemia( CLL).  Preclinical data suggest that it might be more effective than Rituxan in variety of lymphomas.  In early clinical trials, ofatumumab demonstrated single-agent activity against chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin's lymphomas. It was approved by the US Food and Drug Administration for the treatment of CLL that is resistant to both fludarabine

Read more
Thalidomide or Lenalidomide and Rituximab for Mantle Cell Lymphoma

Thalidomide, lenalidomide and rituximab have no direct effect on MCL cells. However, both indirectly affect peripheral blood mononuclear cell-mediated cytotoxicity,  and rituximab induces both complement-dependent and antibody-dependent cellular cytotoxicity (ADCC) against MCL cells. Rituximab-induced ADCC is enhanced by lenalidomide and thalidomide. In a 2004 series, thirteen patients of sixteen enrolled (81%) experienced an objective response,

Read more

Fatal error: Call to undefined function fw_blog_pagination() in /home/content/43/9379243/html/wp-content/themes/wisdom/blog_category.php on line 39