Stem Cell Transplantation

Velcade for Graft Versus Host DIsease – pro

Koreth found that Velcade was beneficial in GVHD; but his was a phase II trial and other phase II trials are ongoing. He found that i the 45 patients who were treated in the study; 89% of patients were treated with a one-locus and 11% of patients were treated with a two-loci mismatch. With a median follow-up of 3 years, the 180-day cumulative incidence of grade 2 to 4 acute GVHD was 22%, and the 1-year cumulative incidence of chronic GVHD was 29%.

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Allogeneic Transplant for ALL – pro

Lay Summary: The accepted situations that warrant allogeneic transplants for ALL are discussed. Most current induction regimens for adult acute lymphoblastic leukemia (ALL) include prednisone, vincristine, and an anthracycline. Some regimens also add other drugs, such as asparaginase or cyclophosphamide. Current multiagent induction regimens result in complete response rates that range from 60% to 90%. However some patients relapse and salvage therapy

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Second Allogeneic Transplant in ALL – pro

ALL is the most common cancer diagnosed in children and young adults represents almost 25% of cancers in children younger than 15 years. Complete remission of disease is now typically achieved with pediatric chemotherapy regimens in approximately 95% of children with ALL, with up to 85% long-term survival rates. Young adults are treated as children, but the relapse rate is higher. Relapsed patients can re-transplanted, receive DLI or go into clinical

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Repeat Allogeneic Stem Cell Transplantation for ALL – pro

ALL is the most common cancer diagnosed in children and young adults represents almost 25% of cancers in children younger than 15 years. Complete remission of disease is now typically achieved with pediatric chemotherapy regimens in approximately 95% of children with ALL, with up to 85% long-term survival rates. Young adults are treated as children, but the relapse rate is higher. Relapsed patients can re-transplanted, receive DLI or go into clinical

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Stem Cell Transplantation in ALL – pro

Patients with relapsed acute lymphoblastic leukemia (ALL) have an extremely poor prognosis. Patients with acute lymphoblastic leukemia (ALL) who experience a relapse following chemotherapy and maintenance therapy are unlikely to be cured by further chemotherapy alone. These patients should be considered for reinduction chemotherapy followed by allogeneic bone marrow transplantation. Reinduction regimens include the hyper-CVAD protocol and high-dose

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Refractory Acute Lymphocytic Leukemia: Role of Stem Cell Transplantation – pro

Although acute lymphoblastic leukemia is curable in one third of adult patients, results vary greatly on account of different clinical, immunologic, and cytogenetic/genetic characteristics. These data, along with the kinetics of response to early treatment, help establish the individual risk class with considerable accuracy, and support risk-specific treatments that should warrant optimal results with as little as possible nonrelapse mortality. Modern

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