Crohn’s Disease and Ulcerative Colitis

Stem and mesenchymal cell transplantation for Crohn’s disease and Ulcerative colitis – pro

The incidence and prevalence of Crohn’s disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. At the same time, stem cell therapies are gaining a prominent place of interest among clincal investigator. at this time, only phase I studies have been performed and are ongoing in patients with Crohn's disease. Clinical improvements in some IBD patients have been reported

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Stem cell transplantation for Crohn’s – pro

Crohn's disease (CD) is an inflammatory bowel disorder that involves loss of immune tolerance in the gastrointestinal tract and T helper 1 delayed-type hypersensitivity of the gut wall, frequently resulting in granuloma formation. The molecular defect causing CD has not been characterized, but probably involves aberrant T cell function. Although CD often responds to immunosuppressive medication including corticosteroids, azathioprine and 6-mercaptopurine,

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Crohn’s disease and B12 – pro

Crohn’s disease(CD) is a chronic inflammatory condition of the intestine, which can cause damage to the portion of the small intestine where vitamin B12 is absorbed and result in B12 deficiency. There is evidence that taking vitamin B12 supplementation may help to improve low levels caused by Crohn’s disease. However, B12 deficeincy is not inevitable. In a recent study(2010), 22% of CD pateints had low B12 levels.In CD patients, prior small intestinal

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Humira for Ulcerative Colitis – pro

Adalimumab(Humira) is an anti-tumor necrosis factor (TNF) agent that is approved for both inducing and maintaining remission in moderately to severely active Crohn's disease. Small open-label trials and case reports suggest that it can induce responses in both anti-TNF-naive and anti-TNF-treated patients with active ulcerative colitis. This led to a phase III trial sponsored by Abott. In it, of the 248 patients treated with 40mg every other week,

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