Large B-cell Lymphoma

Revlimid and Rituxan for maintenance for lymphoma – pro

Recent studies suggest that lanalidomide and rituxan are effective in relapsed or refractory lymphomas. Revlimid, in particular, shows effectiveness for maintenance in myeloma. Because both drugs are well tolerated, this created an interest in studying their effectiveness for maintenance. Currently, maintenance is not standard for most lymphomas, including Diffuse Large B Cell lymphoma. Lenalidomide alone is still in studies, for example, Maintenance

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Zevalin and Rituxan for relapsed large cell lymphoma or for consolidation – pro

Zevalin, 90Y-ibritumomab tiuxetan, is a novel radioimmunotherapeutic agent approved forthe treatment of relapsed or refractory, low-grade or follicular B-cell non-Hodgkin's lymphoma (NHL). Zevalin is also indicated for the treatment of previously untreated follicular NHL in patients who achieve a partial or complete response to first-line chemotherapy. 90Y-ibritumomab tiuxetan consists of a murine monoclonal antibody covalently attached to a metal

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How to follow Diffuse Large Cell Lymphoma after completing treatment

Athough CT remains the gold standard for the staging and follow-up of malignant lymphomas, 18F-FDG PET has a potential role in accurately staging disease and in predicting response to therapy.  On the other,  guidelines do not recommend MRI for surveillance. The most common lymphoma is Diffuse Large B0cell Lymphoma(DLBCL).  2012 NCCN Guidelines for DLBCL on p. BCEL-4 recommend CT no more often than every 6 months for 2 years after completion of

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Angioimmunoblastic T-cell – pro

Angioimmunoblastic T-cell lymphoma (AILD) is considered a variety of T-cell lymphoma, which usually occurs in adults. Patients present with profound lymphadenopathy, fever, night sweats, weight loss, skin rash, a positive Coomb's test, and polyclonal hypergammaglobulinemia. It is quite rare and no standrd approach has beend efined. Angioimmunoblastic T-cell lymphoma was formerly called angioimmunoblastic lymphadenopathy with dysproteinemia. Characterized

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Autologous and allogeneic stem cell transplantation for diffuse large cell lymphoma (NHL) – pro

Summary: NHL is currently the second most frequent indication for autologous hematopoietic stem cell transplantation. It is not a useful treatment option for all patients with NHL, but in certain circumstances, autologous stem cell transplantation does provide patients the best opportunity for cure. Diffuse large-cell lymphoma is the most common form of NHL, and autologous stem cell transplantation has been shown to be beneficial in some subsets

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Gemzar and Navelbine salvage for lympnoma – pro

Gemcitabine, vinorelbine and prednisone or otehr drugs are being investigated to treat refractory or relapsed aggressive non-Hodgkin lymphomas (NHL). Lay Summary: Gemcitabine and vinorelbine are somewhat effective but toxic when few options remain, but more investigation is needed.   The optimum therapy for patients with relapsed or refractory aggressive NHL not qualifying for platinum-based and/or high-dose chemotherapy is not known. In one 

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Rituximab, gemcitabine, oxaliplatin salvage chemotherapy for Non-Hodgkin’s Lymphoma – pro

The study that suggests that the combination of gemcitabine, rituximab, oxaliplatin, and pegfilgrastim iseffective as a  salvage regimen for relapsed non-Hodgkin’s lymphoma (NHL) and is less toxic was presented at the 2008 meeting of the American Society of Clinical Oncology in Chicago May 30-June 2.It included 37 patients with relapsed aggressive NHL treated with gemcitabine, rituximab, oxaliplatin (GROC) and pegfilgrastim given every 14 days.

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Mozobil – pro

Mozobil, a novel small molecule CXCR4 chemokine receptor antagonist, has been shown in multiple earlier studies to rapidly and effectively increase the number of stem cells in circulation in the blood in patients with non-Hodgkin's lymphoma and multiple myeloma. Once circulating in the blood, stem cells can be collected for use in an autologous stem cell transplant. While G-CSF is the standard mobilizing agent for PBSC donors, it is associated with

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Central Nervous System Prophylaxis for Diffuse Large Cell Lymphoma – pro

  There remains an open question about whether intermediate risk lymphomas, such as diffuse large cell lymphomas, with extranodal involvement require prophylaxis against CNS involvement alongside IV chemotherapy, because there is a higher risk of the involvement in these sanctuary sites in these cases.  Such prophylaxis can be intrathecal or high dose methotrexate with follinic acid rescue. The consensus is that some, such as testicular lymphoma,

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Revlimid for refractory relapsed B-cell lymphoma – pro

Revlimid is an orally administered derivative of thalidomide, which is a very active agent for the treatment of multiple myeloma but has serious side effects, especially thromboembolism. Revlimid is reported to have less toxicity than thalidomide but retains antimyeloma effects. Revlimid has recently been approved by the FDA for review of treatment of myelodysplastic syndromes (MDS) wih a 5q- mutation and for first line treatment of multiple myeloma

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