Drugs

Megace ES and Megace; What does bioequivalence mean? – pro

The advantage is in the concentrated dose that Megace ES offers in contrast to Megace. Megace ES (megestrol acetate) oral suspension is indicated for the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). The recommended adult initial dosage of Megace ES (megestrol acetate) oral suspension is 625 mg/day (5 mL/day or one teaspoon daily). The equicaletn

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Zofran – patterns of use – pro

Ondansetron (Zofran) had been FDA approved for two decades and highly effective for nausea and vomiting. It is indicated for: Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin ≥ 50 mg/m2. Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. Prevention of nausea and vomiting associated with radiotherapy in patients receiving

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Cymbalta for oxaliplatin induced neuropathy – pro

Oxaliplatin induced neuropathy can be difficult to manage. Two recent phase II studies suggested that Cymbalta(duloxetine) is effective for oxapliplatin induced neuropathy. Both studies were in small number of patients and there was a significant monority of patients who did not tolerate treatment. Overall benefit was modest. Both studies concluded that using this drug is feasible. This was followed by an abstract at 2012 ASCO meeting of a phase

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Sancuso Patch -pro

SANCUSO® (Granisetron Transdermal System) is indicated for the prevention of nausea and vomiting in patients receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days duration; some studies show that it is effective for up to 7 days. SANCUSO has been studied in head and neck cancers, gastrointestinal cancers, breast cancer and gynecological cancers. It seems particularly suited for prevention of delayed nausea

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Provigil for Cancer Fatigue – pro

NCCN recommends psychostimulants for some cases of severe cancer related fatigue. Provigil was not designed for cancer patients, it is used mainly to treat people with narcolepsy. It has some troublesome side effects. In a clinical trial for narcolepsy, 74 of the 934 patients (8%) who received PROVIGIL dropped out compared to 3% of patients that received placebo. The most frequent reasons for stopping Provigil were headache, nausea, anxiety, dizziness,

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