Monthly Archives: December 2012

Why exercise is important?

  Medical science has found that regular mild exercise has many positive health benefits. Mainstream media has brought this message to the broad public. Yet, exercise need not be hard work. A sedentary individual can benefit even from adding just a few physical activity routines to his or her day. Take the stairs instead of the elevator. Walk during your lunch break. Do jumping jacks during work  breaks. It is not all that difficult to incorporate

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Strep throat

  Sore throat, or pharyngitis, is diagnosed in 11 million people annually in theUnited States. Although most cases are viral, group A beta-hemolytic streptococcus causes 15—30% of the cases in children and 5—20% in adults.Cases usually occur in late winter and early spring. Strep throat is a common problem in large households, where it is a dreaded visitor. After one child picks it up, it is not long before every boy and girl in the family

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All You Ever Wanted To Know About Smoking But Were Afraid to Ask

By Dr. Mark Levin When Columbussailed  from Spain in search of spices and gold, he hardly expected that among his most treasured finds would be… tobacco. On October 12, 1492, Columbuslanded on an island in the Bahamaswhich he named San Salvador, and on October 15 the natives brought him gifts of, as he wrote in his journal, “fruit, wooden spears, and certain dried leaves which gave off a distinct fragrance.” Not knowing what these leaves wereColumbus

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Multivitamins

Few people know that vitamins were discovered by a Jewish researcher who worked in France.  Casimir Funk (1884-1967) who was born in Warsaw discovered thiamine when he worked in the Pasteur Institute in Paris. Before coming to the United Statesin 1915. Funk realized that  that certain food factors were needed to prevent nutritional-deficiency diseases, such as beriberi (vitamin B 1 deficiency), scurvy (vitamin C deficiency), pellagra ( niacin deficiency),

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What is fever?

Most people know about fever is but may have trouble explaining what it is.  Because fever is a common medical condition, it is worthwhile to understand what it is, why it happens and what it means. What is Fever? Fever is defined as an elevation of body temperature above the normal range of 36.5–37.5 °C (98–100 °F). It is triggered by a signal from the temperature regulatory center in the brain in response to a message from the body that

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Stivarga for GIST tumors

GIST(Gastrointenstinal Stromal Tumor)  is the most common form of sarcoma in the gastrointestinal tract. There are thought to be 4,000-5,000 new cases of GIST diagnosed each year in the USA,  about 1,500 of them metastatic. Two treatments for GIST has been recently FDA approved. Recently, FDA also approved regorefanib, Stivarga, for colon cancer, based on the CORRECT trial. The application for approval is for GIST is now pending before the FDA.

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Regorefanib for GIST (Gastrointenstinal Stromal Tumor) – pro
Senior man getting his heart beat checked by a doctor

GIST is the most common form of sarcoma that is found in the gastrointestinal tract. There are thought to be 4,000-5,000 new cases of GIST diagnosed each year in the USA, of them about 1,500 metastatic. New treatments for GIST continue to appear. The most recent candidate for accelerated approval before FDA is regorefanib, recenlty approved as Stivarga for colon cancer. The application for approval is based on the recent GRIP study of 132 patients

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Melanoma: Retreating with Yervoy

Yervoy is recently approved drug that induces an ummune response against melanoma cells. )Some patients have only a partial response or progress afer responding, and owing to there not being many other good options, many doctors would retreat in such a situation. However, Yervoy is a toxic drug and the decision to use it again is not a trivial one. It is , unfortunately, not known whether retreatment is beneficial. There is a study looking at

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Retreatment with Yervoy – pro
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  Ipilimumab(Yervoy) is directed against an antigen on the surface of T cells. It is an FDA approved drug for the treatment of unresectable or metastatic melanoma. Some patients have only a partial response or progress and many physicians would retreat in such a situation. Due to potentially severe or even fatal safety issues, the FDA approved this agent with a Risk Evaluation and Mitigation Strategy (REMS) to ensure the benefits of the agent

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Insomnia in cancer patients – pro
Handsome doctor talking with his patient for the annual check-up

Insomnia of cancer patients can be a manifestation of chemotherapy, antiemetics or steroid drugs,  inadequately treated pain or anxiety and stress, and a workup for insominia is resonable to require.  Cognitive-behavioral therapy appears to be effective for the treatment of insomnia in the general population and also has been upgraded to "likely to be effective" in the Oncology Nursing Society Putting Evidence Into Practice weight of evidence

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