Neurology

Rituxan for Opsoclonus Myoclonus Syndrome – pro

Rituxan has been reported to alleviate the myoclonus opsoclonus syndrome in case reports and series. Presumably there is an immunologic mechanism underlying this observation. Approximately 50 % of patients with OMS have an associated neuroblastoma or associated infections have also been reported.  There is no specific diagnostic biomarker for OMS. Other treatments include as ACTH, corticosteroids, cyclophosphamide and/or intravenous immunoglobulin,

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The Role of Physical Therapies in Muscular Dystrophies – pro

Muscular dystrophy (MD)is a group of genetic diseases that affect muscle function. There are more than 30 genetic mutations that can cause muscular dystrophy. Based on the clinical features, including inheritance pattern, muscles affected, and muscle biopsy features, dystriophis are dvivided into: Duchenne, Becker, Myotonic dystrophy, Facioscapulohumeral, Limb-girdle, Ocullopharyngeal, Congenital and Distal. Physical therapy, especially regular stretching,

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Neuropsychological Testing in Multiple Sclerosis: Importance of Brevity – pro

Data shows strong relationships of neuropsychological testing with neuropsychiatric features of the disease, brain imaging and vocational outcomes (1l). Unfortunately, full neuropsychological testing is time consuming and expensive, which limits its usefulness as an ongoing assessment tool. The current tendency is to seek instruments for evaluation which combine diagnostic efficiency, clinical usefulness and brevity. There are current procedures

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Rituxan in Chronic Demyelinating Polyneuropathy (CDIP) – pro

Rituximab is a chimeric monoclonal antibody that targets the CD20 antigen on B lymphocytes. Depletion of B lymphocytes may interfere with antibody-dependent, cell-mediated cytotoxicity involving peripheral nerve. Several recent reports have suggested that rituximab is beneficial in patients with immune-mediated neuropathies.Evidence for Rituxna's efficacy in CDIP comes mainly from case reports and series and a small placebo controlloed study(Dalakas

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Transverse Myelitis – pro

Transverse myelitis is an inflammatory condition of the spinal cord, which affects thel covering of the nerve cell fibers (myelin). Transverse myelitis causes diminished or absent sensation below the level of the injury injury. The disrupted transmission of nerve signals due to transverse myelitis can cause pain or other sensory problems, weakness or paralysis of muscles, or bladder and bowel dysfunction. Transverse meylitis has been associated with

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MRI in the Diagnosis and Followup of Multiple Sclerosis – pro

Magnetic Resonance Imaging (MRI) of the brain is useful in the diagnosis and treatment of multiple sclerosis (MS), because it is an inflammatory, demyelinating condition of the central nervous system (CNS) that MRI can visualize. Therefore, the activity of the disease can be quantified and tracked over time, with treatment. White matter tracts are affected, including those of the upper brain, lower brain, and spinal cord. MS lesions, known as plaques,

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