Chemoradiation after resection is well established for glioblastoma. Three randomized studies, MR, EIRTC and RTOG have all showed a benefit for it.TEMODAR® (temozolomide) is indicated for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment. One way to dose Temodar is with the Stupp protocol: Temodar 75 mg/m2 for 42 days with radiation. This is the dose and schedule in the Prescribing Information. NCCN also recommends combined chemoradiation.
Siew-Ju See, MRCP (UK), Mark R Gilbert Chemotherapy in Adults with Gliomas Ann Acad Med Singapore 2007;36:364-9
nccn, Centeral Nervous System, 2012
Mei-Yin C. Polley, Kathleen R. Lamborn, Susan M. Chang, Nicholas Butowski, Jennifer L. Clarke and Michael Prados
Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide Neuro Oncol (2010) 12 (3): 274-282.
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