Adjuvant Therapy for Early-Stage Marginal Zone Lymphoma – pro
Extranodal marginal zone lymphoma, also called low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), is an extranodal lymphoma that arises in a number of locations, including the stomach, salivary glands, lung and small intestine. There is evidence for marginal zone lymphoma in general that it might be disseminated at presentation. Therefore, it is tempting to prescribe adjuvant chemotherapy or rituximab. However that is still an experimental approach.
NCCN on p. NGMLT-2 recommends that extranodal marginal zone lymphoma be treatd with observation after resection. If margins are close, as they were in this case, NCCN recommends radiation. It does not recommend adjuvant Rituxan
nccn.org, non-hodgkin’s lymphoma, marginal zone, 2012
E. Zucca, M. Dreyling2 and On behalf of the ESMO Guidelines Working Group Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol (2010) 21 (suppl 5): v175-v176.
Goda JS, Gospodarowicz M, Pintilie M, et al. Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy. Cancer 2010; 116:3815.
Goda JS, Le LW, Lapperriere NJ, et al. Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity. Int J Radiat Oncol Biol Phys 2011; 81:e659.
Anacak Y, Miller RC, Constantinou N, et al. Primary mucosa-associated lymphoid tissue lymphoma of the salivary glands: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys 2012; 82:315.
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