Folfox is the standard adjuvant chemotherapy for colon cancer. Capecitabine is also recommended for adjuvant therapy, but to replace contiunous infusion 5Fu rather than as a part of an oxalipatin containing regimen.
Xeloda is generally considered to be eqivalent to 5Fu and it is a 5FU pro-drug. A number of studies suggest that it is as effective as Folfox adjuvantly. A Phase III study showed the chemotherapy combination XELOX (Xeloda + oxaliplatin) to be as effective — in terms of progression-free survival (PFS) — as the current standard treatment, FOLFOX-4 (infused 5-FU/leucovorin + oxaliplatin), in the treatment of advanced (metastatic) colorectal cancer. For adjuvant therapy, we do now know that it is an effective regimen but it is not yet known whether it is as effective as Folfox. A large phase III XELOX-A study randomised patients between oxaliplatin/capecitabine (XELOX n = 937) or bolus 5-FU/LV (n = 924) in stage III colon cancer. data confirm that XELOX, a combination of Xeloda� (capecitabine) and oxaliplatin, is as safe as the current standard treatment of intravenous 5-fluorouracil/leucovorin (i.v. 5-FU/LV) in adjuvant colon cancer patients (post-surgery). Moreover, XELOX reduces the number of hospital visits by more than 60 percent compared to the current standard therapy, providing patients the freedom to live as normal a life as possible
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