Chromophobe (ChRCC) Type Renal Cell Cancer – pro
Chromophobe(ChRCC) renal cell cancer is rare. Unfortunately, there are no proven treatment for the metastatic disease. At one time chemotherapy was thought to be effective but studies did not confirm it. Overexpression of CD117 on cellular membranes of ChRCC could be a potential target for kinase inhibitors like: imatinib, dasatinib, nilotinib. The potential targets for other kinase inhibitors (sunitinib and sorafenib) in ChRCC seem to be VEGFR and PDGFR. In conclusion, these observations are the basis for formulating research hypotheses which should be verified in prospective studies.
B. Escudie,r V. Kataja Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol (2010) 21 (suppl 5): v137-v139.
Rafał Stec et al, Chromophobe renal cell cancer – review of the literature and potential methods of treating metastatic disease Journal of Experimental & Clinical Cancer Research 2009, 28:134
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, Negrier S, Ou YC, Castellano D, Lim HY, Uemura H, Tarazi J, Cella D, Chen C, Rosbrook B, Kim S, Motzer RJ Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet. 2011 Dec 3;378(9807):1931-9.