Occasionally in early endometrial cancer the best teatment, surgery, is not possible. There is very litlle information on what to do in such situations. In advanced endometrial cancer there are some physicians who think that radiation is as good as chemo. There is a study: Radiation Therapy Compared With Combination Chemotherapy inTreating Patients With Advanced Endometrial Cancer, NCT00002493. It is a Randomized phase III trial to compare radiation therapy with chemotherapy in treating patients who have advanced endometrial cancer.
There is a statement of NCCN on p.32 of the text that accompanies the guideline: ” For medically inoperable patients… radiation therapy has been demonstrated as a well tolerated and effective treatment that can provide some measure of pelvic control and long-term progression free survival”.
B. Anderson, S. Bentzen, R. Das, M. Straub, K. Bradley
Single Institution Experience Treating Medically Inoperable Stage I Endometrial Cancer with High-dose Rate Intracavitary Brachytherapy
International Journal of Radiation Oncology*Biology*Physics, Volume 72, Issue 1, Supplement 1, 1 September 2008, Page S370
Jiade J. Lu and Luther W. Brady
Book Series Medical Radiology
An Evidence-Based Approach