Etoposide and carboplatin for glioblastoma – pro

The use of paraplatin and etoposide for glioblastomas cannot be called standard. This regimen is not particularly effective, based on phase II studies. Some of these older studies conclued that it was not effective and others urged fartehr exploration. There were some responses in these studies and this regimen is now being studied again with the addition of newer agents.Moshe E. Stein et al, Carboplatin and etoposide for recurrent malignant glioma following surgical and radiotherapy failure: A clinical study conducted at the Northern Israel Oncology Center

Jeremic B, Grujicic D, Jevremovic S, Stanisavljevic B, Milojevic L, Djuric L, Mijatovic L. Carboplatin and etoposide chemotherapy regimen for recurrent malignant glioma: a phase II study.J Clin Oncol. 1992 Jul;10(7):1074-7

E Franceschi et al, Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma, British Journal of Cancer (2004) 91, 1038-1044.

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