Ganglioglioma – pro

Gangliogliomas are rare pediatric brain tumors composed of transformed neuronal and glial elements, with rare malignant progression of the glial component, that are fortunately associated with a high rate of cure. Only about 10% behave aggessively. Because of their rarity, no prospective studies have been performed regarding gangliogliomas. Data suggest a historic 20-year survival rate of approximately 80 percent. According to a recent review of four types of treatment (Zwick et al), Grosss Total Resectoin should be performed whenever safely possible and does not require postoperative irradiation. If resection is subtotal, radiation therapy improves local control of both low-grade and high-grade tumors and, thus, should be considered seriously. Temodar has only been used in a few cases.
Rades D, Zwick L, Leppert J, Bonsanto MM, Tronnier V, Dunst J, Schild SE. The role of postoperative radiotherapy for the treatment of gangliogliomas.Cancer. 2010 Jan 15;116(2):432-42.

Majores M, von Lehe M, Fassunke J, Schramm J, Becker AJ, Simon M. Tumor Recurrence and Malignant Progression of Gangliogliomas. Cancer. 2008;113:3355-3363. Available at: July 7, 2011.

DeMarchi R, Abu-Abed S, Munoz D, Loch Macdonald R. Malignant ganglioglioma: case report and review of literature. Journal of Neuro-oncology. 2011;101:311-318

Ajay Pandita, Anandh Balasubramaniam, Richard Perrin, Patrick Shannon and Abhijit Guha Malignant and benign ganglioglioma: A pathological and molecular study Neuro Oncol (April 2007) 9 (2): 124-134.

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