Gangliogliomas are rare pediatric brain tumors composed of transformed neuronal and glial elements, with rare malignant progression of the glial component, that are fortunately associated with a high rate of cure. Only about 10% behave aggessively. Because of their rarity, no prospective studies have been performed regarding gangliogliomas. Data suggest a historic 20-year survival rate of approximately 80 percent. According to a recent review of four types of treatment (Zwick et al), Grosss Total Resectoin should be performed whenever safely possible and does not require postoperative irradiation. If resection is subtotal, radiation therapy improves local control of both low-grade and high-grade tumors and, thus, should be considered seriously. Temodar has only been used in a few cases.
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