Gleevec for adenoid cystic carcinoma – pro

Gleevec is approved for CML and GIST tumors. It is tempting to use it for other c-kit positive tumors and several case reports seemed to promise activity, but a phase II study published in 2007 found no responses in adenoid cystic carcinoma. A study reported in 2005 was stopped becasuu of the lack of activity.

Pfeffer MR, Talmi Y, Catane R, Symon Z, Yosepovitch A, Levitt M.

A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands.

Oral Oncol. 2007 Jan;43(1):33-6. Epub 2006 Jun 6.

© 2005 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2005.06.125

Sébastien J. Hotte, Eric W. Winquist, Elizabeth Lamont, Mary MacKenzie, Everett Vokes, Eric X. Chen, Shirley Brown, Gregory R. Pond, Anthony Murgo, Lillian L. Siu

Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium StudyJournal of Clinical Oncology, Vol 23, No 3 (January 20), 2005: pp. 585-590

Participate in our Forums

To ask questions or participate in a discussion, please visit our Forums. You must LOGIN to participate.

Help Us Help Others

You can become a Site Sponsor. Or you may wish to support our work with a Donation.

Focused Articles For You

Lay Portal