Gleevec is approved for CML and GIST tumors. It is tempting to use it for other c-kit positive tumors and several case reports seemed to promise activity, but a phase II study published in 2007 found no responses in adenoid cystic carcinoma. A study reported in 2005 was stopped becasuu of the lack of activity.
Pfeffer MR, Talmi Y, Catane R, Symon Z, Yosepovitch A, Levitt M.
A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands.
© 2005 American Society of Clinical Oncology.
Sébastien J. Hotte, Eric W. Winquist, Elizabeth Lamont, Mary MacKenzie, Everett Vokes, Eric X. Chen, Shirley Brown, Gregory R. Pond, Anthony Murgo, Lillian L. Siu
Imatinib Mesylate in Patients With Adenoid Cystic Cancers of the Salivary Glands Expressing c-kit: A Princess Margaret Hospital Phase II Consortium StudyJournal of Clinical Oncology, Vol 23, No 3 (January 20), 2005: pp. 585-590