Granular cell tumor develops on any skin or mucosal surface, but occurs most commonly on the tongue( 40%). It sometimes behaves like a benign tumor and sometimes as a malignancy. Other names for this rare cancer are: Abrikossoff’s tumor, Granular cell myoblastoma, Granular cell nerve sheath tumor, and Granular cell schwannoma. It is now believed that it is a cancerous process, even when it behaves like a benign cancer, and it can always begin to behave more agressively. It is called granular because of the accumulation of secondary lysosomes in the cytoplasm. The literature is based on case reports and series and presents the impression that radiation and chemotherapy are not needed for benign lesions and are not effective for malignant lesions.
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