Hepatoblastoma – pro
Hepatoblastoma is a rare pediatric cancer that can be cured by surgery. Preoperative chemotherapy followed by complete surgical excision according to International Society of Paediatric Oncology guidelines yields excellent results with a current survival rate of 80%.Liver transplantation is a curative option as well.Various chemotherapy regimens have been reported but there are no prospective studies and no studies of second line chemotherapy. Czauderna P, Otte JB, Aronson DC, Gauthier F, Mackinlay G, Roebuck D, Plaschkes J, Perilongo G; Childhood Liver Tumour Strategy Group of the International Society of Paediatric Oncology (SIOPEL).Guidelines for surgical treatment of hepatoblastoma in the modern era–recommendations from the Childhood Liver Tumour Strategy Group of the International Society of Paediatric Oncology (SIOPEL).Eur J Cancer. 2005 May;41(7):1031-6.
Davies JQ, de la Hall PM, Kaschula RO, Sinclair-Smith CC, Hartley P, Rode H, Millar AJ.Hepatoblastoma–evolution of management and outcome and significance of histology of the resected tumor. A 31-year experience with 40 cases.J Pediatr Surg. 2004 Sep;39(9):1321-7.
Pritchard J, Brown J, Shafford E, et al.: Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach–results of the first prospective study of the International Society of Pediatric Oncology. J Clin Oncol 18 (22): 3819-28, 2000. [PUBMED Abstract]
Austin MT, Leys CM, Feurer ID, et al.: Liver transplantation for childhood hepatic malignancy: a review of the United Network for Organ Sharing (UNOS) database. J Pediatr Surg 41 (1): 182-6, 2006. [PUBMED Abstract]
http://www.annalsofhepatology.com/PDF/vol9n1/HP101-13-Hepatoblastoma.pdf
Zsíros J, Maibach R, Shafford E, et al.: Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol 28 (15): 2584-90, 2010.