Ki-67 in gliomas – pro
Ki-67 is a nuclear antigen that is upregulated during cellular proliferation. Ki-67 expression has been both positively and negatively associated with survival in a number of tumors. IN studies of the prognostic value of initial Ki-67 expression for overall survival have reported conflicting results with some suggesting a positive, others a negative, and others no correlation. Some studies calim correlation in lower grade GBM and toehrs in high grade GBM. Because of it, this marker is not of clinical usefullness at this time and research is ongoing.
Minoru Kogiku et al, Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor Journal of Clinical Neuroscience
Volume 15, Issue 11, November 2008, Pages 1198-1203
Barbara J. Fisher et al, Clinical investigation: central nervous system
Ki-67: a prognostic factor for low-grade glioma? International Journal of Radiation Oncology*Biology*Physics Volume 52, Issue 4, 15 March 2002, Pages 996-1001
Jeffrey J. Olson, Camilo E. Fadul, Daniel J. Brat, Srinivasan Mukundan and Timothy C. Ryken Journal of Neuro-Oncology Management of newly diagnosed glioblastoma: guidelines development, value and application Volume 93, Number 1, 1-23,