Neoplastic meningitis – pro

Leptomeningeal metastases (LM) are increasingly recognized as a devastating complication of solid tumors. Improved treatment of primary malignancy and advances in diagnostic imaging have led to an apparent increase in the number of patients diagnosed with LM. Unfortunately, therapeutic options remain limited. Radiotherapy is used to treat bulky tumor and provide symptomatic relief. Intrathecal chemotherapy benefits a selected subset of patients. Given that LM is a cancer complication that can spread throughout the entire subarachnoid space, chemotherapy, whether intrathecal or systemic, is currently considered the best treatment option, when feasible.

Pavlidis, N. Annals of Oncology.The diagnostic and therapeutic management of leptomeningeal carcinomatosis. Educational Book of the 29th ESMO Congress 29 October – 2 November, 2004: Vienna, Austria. 15 Supplement:iv285-iv291, October 2004.

A. Pace, A. Fab, Chemotherapy in neoplastic meningitis.
Critical Reviews in Oncology/Hematology, Volume 60, Issue 3, Pages 194-200 2006

Brian J Scott and Santosh Kesari, Leptomeningeal metastases in breast cancer. Am J Cancer Res. 2013; 3(2): 117126.

Scott BJ, Oberheim-Bush NA, Kesari S. Leptomeningeal metastasis in breast cancer – a systematic review.Oncotarget. 2015 Nov 2. doi: 10.18632/oncotarget.5911. [Epub ahead of print]

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