Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. Most of the use has been for monitoring treatment for osteoporosis but some use it for following metastatic bone disease. There are no guideline or consensus recommendations supporting this test for routine use.
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Yoichi Arai et al, Osteocalcin: Is it a useful marker of bone metastasis and response to treatment in advanced prostate cancer? The Prostate Volume 20 Issue 3, Pages 169 – 177