Salvage GemOX and Rituxan for lymphoma – pro
This regimen was in a recently completed clinical trial, Rituximab, Gemcitabine and Oxaliplatin (R-GEMOX)for Refractory/Relapsed B-Cell Lymphoma, NCT00169195. This is a multicentric, open-label, non-randomized clinical study, evaluating the efficacy and the safety of R-GEMOX in refractory/relapsed patients aged from 18 to 75 years with CD20-positive large B-cell lymphoma non eligible for autologous transplantation. At ASCO 2008 researchers from M.D. Anderson Cancer Center presented data on 37 patients with relapsed aggressive NHL treated with gemcitabine, rituximab, oxaliplatin (GROC) and pegfilgrastim given every 14 days. The results were comparable with other salvage regimens; however, this was not a direct comparison. There was a previous study as well published in the Annals of Oncology in 2007. Thus it is still investigational but with several supporting publications already to its credit.
T El Gnaoui , J Dupuis , K Belhadj , J-P Jais , A Rahmouni , C Copie-Bergman , I Gaillard , M Diviné , I Tabah-Fisch , F Reyes , and C Haioun
Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy Ann Oncol (2007) 18 (8): 1363-1368. .
Corazzelli G, Capobianco G, Arcamone M, et al. Long-term results of gemcitabine plus oxaliplatin with and without rituximab as salvage treatment for transplant-ineligible patients with refractory/relapsing B-cell lymphoma. Cancer Chemother Pharmacol 2009;64(5):907-916.CrossRefMedline
Diffuse large B-cell non-Hodgkin’s lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol (2010) 21(suppl_5): v172-v174