Sprycel for breast cancer – pro

Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. There are several trials, two completed and several ongoing of this drug in breast cancer (http://clinicaltrials.gov/ct2/results?term=dasatinib+breast).
There are studies that show that it is effective alone or with doxorubicin and cusplatin in cell cultures. A phase I and phase II trial reported as poster and abstract respectively suggest that it has modest efficacy in combination with capecitabine. On the other hand, a phase II study showed no effectivenesss in heavily pre-treated breast cancer(Herold et al). FInn et al found “limited” activity. Of the 43 response evaluable patients, ORR was 4.7%: two patients had confirmed partial responses lasting 14 and 58 weeks, respectively. Of 11 patients with stable disease, two continued for more than 16 weeks, thus protocol-defined DCR was 9.3%. Median PFS was 8.3 weeks (95% CI: 7.3-15.3).


G. Somlo, F. Atzori, L. Strauss, A. Rybicki, X. Wu, W. Gradishar, J. Specht;Dasatinib plus capecitabine (Cap) for progressive advanced breast cancer (ABC): Phase I study CA180004.J Clin Oncol 27:15s, 2009 (suppl; abstr 1012)

Tryfonopoulos, D., O’Donovan, N., Corkery, B., Clynes, M., Crown, J. Activity of dasatinib with chemotherapy in triple-negative breast cancer cells J Clin Oncol (Meeting Abstracts) 2009 27: e14605

 Herold CI, Chadaram V, Peterson BL, Marcom PK, Hopkins J, Kimmick GG, Favaro J, Hamilton E, Welch RA, Bacus S, Blackwell KL. Phase II trial of dasatinib in patients with metastatic breast cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing. Clin Cancer Res.2011 Sep 15;17(18):6061-70.


Dasatinib as a single agent in triple-negative breast cancer: results of an open-label phase 2 study.Clin Cancer Res. 2011 Nov 1;17(21):6905-13.


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