BEAM Super is a 9 high dose chemo drugs over 5 days chemo regime. It is unique to the University of Arkansas Myeloma center, an institution which is on the leading age of developing new myeloma treatments. The regimen comprises BCNU at 300mg/m2 on day 1, etoposide 200mg/m2 on days 1-4; cytarabine 400mg/m2 on days 1-5; melphalan 140mg/m2 on day 5 plus: bortezomib 1.0-1.3mg/m2 on days 1+4, thalidomide 100-200mg on days 1-5, dexamethasone 20-40mg days 1-5, cisplatin 10-12.5mg/m2/d by continuous infusion on days 1-5, rapamycin 3mg on day 1 and 1mg on days 2-5; followed by autotransplant (AT) on day 6.
This is a relatively unpublished regimen, although it is in extensive use at University of Arkansas. In general, conditioning regimens have been established on the basis of phase II studies; there are only a few comparative studies of different conditioning regimen. This Super-BEAM regimen is ahead of the “curve” and should be considered experimental. Very little has been published on it as of yet and we await more.
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