Sutent® (sunitinib malate) has been shown to significantly increase progression-free survival in patients with advanced pancreatic islet cell tumors, leading to a halt in the Phase III trial. For pancreatic adenocarcinoma, preliminary analysis of a large cooperative group phase II study suggests modest single agent activity. There is an ongloing phase II trial: Sunitinib in Treating Patients With Metastatic Pancreatic Cancer That Progressed After First-Line Therapy With Gemcitabine, NCT00397787.
Pfizer Inc. Press Release March 12, 2009: http://mediaroom.pfizer.com/news/pfizer/20090312005308/en
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Burris, Howard, III , Rocha-Lima, Caio
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