Tumor fever can occurr in lymphoma but is more often seen in other malignancies. Nonsteroidal anti-inflammatory agents can reduce this fever, and often make to dissappear completely.Indocin is the best reported such agent. It is often taught as medical “lore” that if the fever completely dissappears, it is an indication that it was tumor related, wereas simple dampening of the fever curve suggests that other causes are at work. This is a working principle but not fully reliable. Some suggest that treatment with Indocin can serve as a test to differentiate fever types; again, this is not widely accepted.
AKentaro Yoshinaga et al, Anti-lymphoma effect of naproxen and indomethacin in a patient with relapsed diffuse large B-cell lymphoma American Journal of Hematology
Volume 66 Issue 3, Pages 220 – 223
Engervall, P Björkholm, M Grimfors, G Holm, G Antipyretic effect of indomethacin in malignant lymphoma.ACTA MEDICA SCANDINAVICA Vol. 219 Issue 5 1986
Barrier J, Roblot P, Ramassamy A, Becq-Giraudon B.[Is the indomethacin test able to indicate the etiological diagnosis of isolated fever?][Article in French]Rev Med Interne. 1995;16(9):658-61
See Fever of Unknown Origin