Xeloda is a 5FU prodrug that is now believed to produce effects similar to 5FU, although the equivalence has not been proven in all cancer types. The European Commission has approved oral chemotherapy Xeloda (capecitabine) for the treatment of metastatic colorectal cancer in combination with any chemotherapy in all lines of treatment with or without Avastin. While the FDA had not specifically approved Xeloda with Avastin, it indicated Avastin with 5 FU containing regimens and expert consensus is that multiple studies have shown that Xeloda is at least equivalent to 5FU in colorectal cancer. Xeloda and Avastin is also NCCN recommended but as Folfox/Avastin/Avastin or Xelox/Avastin. However, there are two phase II trials supporting Xeliri/Avastin and I referenced them.
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