Xeloda and erbitux for colorectal cancer – pro

Xeloda is FDA approved and so is Erbitux as a single agent. Monoclonal antibodies such as cetuximab, can block tumor growth in different ways. Giving cetuximab together with capecitabine may kill more tumor cells. This is still being investigated.

When Xeloda is used with cetuximab, it would be considered experimental. There is a Phase II trial: Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That Failed Irinotecan Treatment, NCT00538291. ANnther relevant study is: Study of Capecitabine and Cetuximab as First-Line Therapy in Patients With Metastatic Wild Type Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Colorectal Cancer, NCT00954876. Patients who are not able or willing to take Oxaliplatin/Irinotecan combination therapy are eligible for this study but note that this is a first line study. There are a number of ongoing trials that also add oxalipatin, irinotecan or cisplatin, or radiation.
J. P. Machiels, C. Sempoux, P. Scalliet, J. C. Coche, Y. Humblet, E. Van Cutsem, J. Kerger, J. L. Canon, M. Peeters, S. Aydin, S. Laurent, A. Kartheuser, B. Coster, S. Roels, J. F. Daisne, B. Honhon, L. Duck, C. Kirkove, M. A. Bonny, K. Haustermans
Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann Oncol, Vol. 18, No. 4. (April 2007), pp. 738-744.

Viudez, A., Zarate, R., Garrido, M., Rodriguez, J., Chopitea, A., Fernandez-Troconiz, I., Pardo, F., Garcia-Foncillas, J.
Dose escalation of capecitabine in combination with biweekly cetuximab and hepatic arterial infusion (HAI) of oxaliplatin in patients with liver metastases of colorectal cancer: Preliminary clinical results
J Clin Oncol (Meeting Abstracts) 2009 27: e15080

Ibrahim EM, Zeeneldin AA, Al-Gahmi AM, Sallam YA, Fawzi EE, Bahadur YA. Safety and efficacy of cetuximab-chemotherapy combination in Saudi patients with metastatic colorectal cancer. Indian J Cancer 2007;44:56-61

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