Thymoma is usually treated with surgery. Where surgery is inappropriate, chemotherapy concurrent with, or sequential to, radiation therapy is recommended. Cisplatin-based combination chemotherapy is an appropriate option. Octreotide, alone or in combination with a corticosteroid, may be a reasonable option for recurrent cases. A recent Phase II study revealed that complete responses (CR) and partial responses were observed in three (20%) and three (20%) patients for a 40% RR, respectively. Grade 1–2 neutropenia, anemia and thrombocytopenia were the most common side-effects, noted in seven (46.7%), five (33.3%) and five (33.3%) patients, respectively. The most common grade 3 toxicity was neutropenia in three patients (20%). Median PFS was 11 months (95% confidence interval 4–17). The 1- and 2-year survival rates were 80% and 67%, respectively. There are other phase II trials that also suggest that cepacitabine in combination is effective.
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