Xeloda to prevent skin cancers organ transplantation

Skin cancers, especially squamous cell cancers,  are very common after solid organ transplantation, such as heart, lung, pancreas, liver and kidney.  The incidence of skin cancer varies from country to country and appears to be higher with exposure to sunlight. This incidence is higher in sunny Australia, as high as 45 and 70% at 10 and 20 .

A recent report by Jirakulaporn suggests that taking prophylactic Xeloda can prevent at least some of these cancers. Fifteen patients (13 men and two women) with a median age of 57 yr (range 40-73) were treated. Incidence rates as measured by mean number of events per month declined by 0.33 for SCC, 0.04 for BCC, and 2.45 for AK (p < 0.05). The most common grade 3 and 4 toxicities included fatigue (40.0%), hand-foot syndrome (20.0%), and diarrhea (20.0%).

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