RAI) is used in treatment of patients with differentiated papillary and follicular thyroid cancer. It is typically used after thyroidectomy, both as a means of imaging to detect residual thyroid tissue or metastatic disease, as well as a means of treatment by ablation if such tissue is found.
There is little dispute that patients with incomplete resections and grossly positive margins in DTC are at high risk of recurrence as well as disease-specific death. The 2009 ATA management guidelines consider patients with microscopically positive margins to be at an increased risk of recurrence been questioned, radioactive iodine ablation for positive margins remains accepted. NCCN does not list it, but it does list lymphatic invasion among other factors as a reason to give iodine ablation.
Marilee Carballo et al, To Treat or Not to Treat: The Role of Adjuvant Radioiodine Therapy in Thyroid Cancer Patients. Journal of Oncology Volume 2012 (2012), Article ID 707156,Laura Y. Wang et al,Microscopic Positive Margins in Differentiated Thyroid Cancer Is Not an Independent Predictor of Local Failure Thyroid. 2015 Sep 1; 25(9): 993998.
NCCNC, Thyroid PAP-4 2017 |