Histotrypsy – pro
Histotripsy is a non-invasive procedure that uses high-intensity sound waves to selectively destroy cancer tissue in the liver. The procedure uses a precise machine to generate and target sound waves that create a “bubble cloud,” which disrupts and destroys only the cancerous tissue. It had been recently granted marketing authorization by the FDA.Histotripsy forms microbubbles within tumors by subjecting them to acoustic waves of high pressure-focused ultrasound. Once the sound waves converge at a focal point targeting the tumor, mechanical cavitation occurs and results in cell death. This then creates an environment where the immune system can identify and “clean up” tumor debris, abscopal effect.
The use of histotrypsy fo a metastatic sidte in order to provoke the absocpal effect is currently not well supported and is E.I.
LeBlang, S., & Ziemlewicz, T. J. (2024). The art of histotripsy: a focused ultrasound application that has the potential to treat from head to toe! International Journal of Hyperthermia, 41(1).
Wah TM, Pech M, Thormann M, et al. A multi-Centre, single arm, non-randomized, prospective european trial to evaluate the safety and efficacy of the HistoSonics system in the treatment of primary and metastatic liver cancers (#HOPE4LIVER). Cardiovasc Intervent Radiol. 2023;46(2):259–267.
Hay AN, Ruger L, Hsueh A, et al. A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments. Int J Hyperthermia. 2023;40(1):2274802.
Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy 2020