Second line chemotherapy for small cell lung cancer – pro
NCCN has a variety of recommendations for second line therapy,all single agents, including irinotecan alone but not cisplatin/ irinotecan. Irinotecan and etoposide did not show any advantages over single agents. Amrubicin and topotecan seem to perform marginally better.
NCCN. Small Cell Lung Cancer, 2014
Schmittel A et al, Second-line therapy for small-cell lung cancer.Expert Rev Anticancer Ther. 2011 Apr;11(4):631-7
Luo Q et al, Efficacy of different monotherapies in second-line treatment for small cell lung cancer: a meta-analysis of randomized controlled trials.Int J Clin Exp Med. 2015 Oct 15;8(10):19689-700.