Allogeneic stem cell transplantation for hepatosplenic T-cell lymphoma–pro
Hepatosplenic T-cell lymphoma (HSTCL) is a rare but aggressive type of non-Hodgkin lymphoma that primarily involves the sinusoids of the liver, red pulp of the spleen and the sinuses of the bone marrow. This is a fairly rare condition but there are 2 large analysis.Using an exhaustive review of the literature It can be demonstrated demonstrated that as many as 40% of patients with HSTCL who undergo allo-SCT have durable RFS. Interestingly, active disease at the time of SCT did not predict poor outcomes, highlighting the potency of the graft-versus-lymphoma effect.
Taken together, female gender seemed to be independently associated with longer RFS and OS, due to lower TRM.
A Rashidi and A F Cashen et al, Outcomes of allogeneic stem cell transplantation in hepatosplenic T-cell lymphoma. Blood Cancer J. 2015 Jun; 5(6): e318.
11Tanase A, Schmitz N, Stein H, Boumendil A, Finel H, Castagna L et al. Allogeneic and autologous stem cell transplantation for hepatosplenic T-cell lymphoma: a retrospective study of the EBMT Lymphoma Working Party. Leukemia 2015; 29: 686–688