Cabometyx for HCC – pro
Treatment with cabozantinib (Cabometyx) improved median overall survival (OS) by 2.2 months compared with placebo for patients with previously treated advanced hepatocellular carcinoma (HCC), according to findings from the phase III CELESTIAL trial presented at the 2018 Gastrointestinal Cancers Symposium.
Median OS was 10.2 months with cabozantinib versus 8.0 months with placebo (HR 0.76, 95 percent CI 0.63-0.92; p=0.0049). Median progression-free survival (PFS) was more than doubled, at 5.2 months with cabozantinib and 1.9 months with placebo (HR 0.44, 95 percent CI 0.36-0.52; p<0.0001). Objective response rates per RECIST 1.1 were 4 percent with cabozantinib and 0.4 percent with placebo (p=0.0086). Disease control (partial response or stable disease) was achieved by 64 percent of the cabozantinib group compared with 33 percent of the placebo group.
Ghassan K. Abou-Alfa, Tim Meyer, Ann-Lii Cheng, Anthony B. El-Khoueiry, Lorenza Rimassaet al, Cabozantinib (C) versus placebo (P) in patients (pts) with advanced hepatocellular carcinoma (HCC) who have received prior sorafenib: Results from the randomized phase III CELESTIAL trial. Journal of Clinical Oncology 36, no. 4_suppl (February 1 2018) 207-207.