BRAF targeted treatment for polymorphic xanthoastrocytoma – pro
There are several case reports of treating these cancers with BRAF mutations, if present, with BRAF drugs, but not a sufficient literature basis for the proposed treatment.
Aisner DL, Newell KL, Pollack AG, Kleinschmidt-Demasters BK, Steinberg GK, Smyth LT, Vogel H.
Composite pleomorphic xanthoastrocytoma-epithelioid glioneuronal tumor with BRAF V600E mutation – report of three cases. Clin Neuropathol. 2014 Mar-Apr;33(2):112-21.
Giuseppe Petruzzellis et al, Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome Front. Oncol., 12 April 2019
Del Bufalo F, Ceglie G, Cacchione A, et al. BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas. Front Oncol. 2018;8:526. Published 2018 Nov 14.