Neupogen (filgrastim) for miscarraige prevention and fertility – pro
Cavalcanter et al reviewed the available literature ni 2015 asd concluded: “Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.”.A metaanalysis in 2015 (Kamath et al) says: “Findings of current review suggest a possible benefit of G-CSF in women with thin endometrium undergoing ART and RIF. However these findings need to be further validated in larger trials before G-CSF can be used in routine clinical practice.”
Würfel W, Santjohanser C, Hirv K, et al. High pregnancy rates with administration of granulocyte colony-stimulating factor in ART-patients with repetitive implantation failure and lacking killer-cell immunglobulin-like receptors. Hum Reprod. 2010;25(8):21512152. doi:10.1093/humrep/deq106
Cavalcante MB, Costa Fda S, Barini R, Araujo Júnior E. Granulocyte colony-stimulating factor and reproductive medicine: A review. Iran J Reprod Med. 2015;13(4):195202.
Kamath MS, Chittawar PB, Kirubakaran R, Mascarenhas M.Use of granulocyte-colony stimulating factor in assisted reproductive technology: A systematic review and meta-analysis.Eur J Obstet Gynecol Reprod Biol. 2017 Jul;214:16-24