RAD51C mutation – pro
NCCN guidelines recommend that women with an inherited mutation in RAD51C consider risk-reducing oophorectomy at age 45-50 or earlier based on a family history of cancer. Other options, including participating in detection and prevention research studies, may be available to manage risk.
Lu W, Wang X, Lin H, Lindor NM, Couch FJ. Mutation screening of RAD51C in high-risk breast and ovarian cancer families. Fam Cancer. 2012;11(3):381‐385.
Jønson L, Ahlborn LB, Steffensen AY, Djursby M, Ejlertsen B, Timshel S, Nielsen FC, Gerdes AM, Hansen TV (January 2016). “Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer”. Breast Cancer Research and Treatment. 155 (2): 215–22.
NCCN, Familial breast and ovarian cancer, screening. 2020