Autologous stem cell transplantation for plasma cell leukemia – pro

Primary plasma cell leukemia is a rare disorder accounting for less than 5% of malignant plasma cell diseases. It has a poor prognosis compared to multiple myeloma, with a median survival of 8–12 months. The results of conventional therapy are disappointing though autologous stem cell transplantation appears to improve survival.

 

Autologous stem cell transpatntation is well accepted for multiple myeloma. For plasma cell leukemia, a variant of myeloma, there are studies that show improved prognosis, albeit not tot eh same extent as in multiple myeloma.

Drake MB, Iacobelli S, van Biezen A, et al. Primary plasma cell leukemia and autologous stem cell transplantation. Haematologica. 2010;95(5):804?809. doi:10.3324/haematol.2009.013334Gowda, L., Shah, M., Badar, I. et al. Primary plasma cell leukemia: autologous stem cell transplant in an era of novel induction drugs. Bone Marrow Transplant 54, 1089–1093 (2019).

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